The Sweet 16 of the 2022 NCAA women's basketball tournament tips off Friday in the Greensboro and Spokane regions.

But March Madness has had its share of upsets, as two No. 10 seeds

the Creighton Bluejays and South Dakota Coyotes, will play in the Sweet 16 for the first time in their programs' history.

What's the best game when the next round tips off?

And which teams will leave the Bridgeport, Greensboro, Spokane and Wichita regionals as champions

ESPN's Charlie Creme, Alexa Philippou and Mechelle Voepel preview and predict the regionals

These are two outstanding offensive teams, and when the Terrapins are clicking

they are a point-producing machine. But Stanford is also an elite defensive team. That, and the Cardinal's depth

Her Hoops Stats rates Stanford as the third-best defensive team in the country.